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D-Mannose 500 + Cranberry 255 mg is a dietary supplement made from D-Mannose, Cranberry, Bearberry and Vitamin C. Cranberry is useful for draining excess fluid and when combined with Bearberry acts synergistically to promote the urinary tract function. Vitamin C also supports the normal function of the immune system. The formula is enriched with 500 mg of D-Mannose. D-Mannose targets only E. coli and leaves all your good bacteria alone. D-Mannose takes a kinder, gentler approach; it doesn’t kill anything. Rather, it flows through your kidneys and urinary tract, sticking to the E. coli along the way and together they are excreted.